Scientific board

Alexis Forterre


Alexis Forterre has expertise in the field of molecular/cellular biology and the role of extracellular vesicles (exosomes) in the inter-organs communication. Member of the FSEV (French Society of Extracellular Vesicles), one of his main research interests is related to the therapeutic use of exosomes for drug, proteins and RNA specific delivery to targeted cells/tissues.

  •  With a PhD in Cell Biology and Physiology (University of Claude Bernard Lyon1, France) on the roles of skeletal muscle-secreted Extracellular Vesicles during myogenesis and during the T2DM-associated insulin resistance.
  • With two postdoctoral experiences in American universities (University of Notre Dame, Indiana; and Stanford University, California) on extracellular vesicles biogenesis and on designing therapeutic strategies for the specific delivery of drugs and RNAs.
  • Currently Project manager “Muscles and pancreatic islets interactions” in the unit DIATHEC (EA 7294, Diabète & Thérapeutique, CeeD)

Pierre Gianello


Pierre Gianello, whose international reputation in the field of xenotransplantation and diabetes no longer has to be proved, provides an overview of the diabetes problem to the scientific council of Defymed.

  • Transplant surgeon and researcher in transplantation immunology, director of the laboratory of experimental surgery at the Catholic University of Louvain in Brussels
  • An international opinion leader in the encapsulation of pancreatic islets used to restore blood glucose levels in animal models with type 1 diabetes
  • Member of several scientific councils and winner of many international awards

Paul Johnson


Paul Johnson is a world expert in pancreatic islet transplantation. He has an innovative clinical vision of diabetes cell therapy, leading a ‘bench to bedside’ research program that places the patient at the center of development of Defymed medical devices.

  • Professor of Pediatric Surgery at the University of Oxford and Director of the Oxford Pancreatic Islet Transplant Program; founding member of the UK Islet Transplant Consortium (UKITC) -the first fully-funded national islet program
  • Chair of the NHS UK Islet Transplant Steering Group and Former President of IPITA (International Pancreas & Islet Transplant Association)
  • International opinion leader in pancreatic islet isolation and islet transplantation

Nathalie Jeandidier


Nathalie Jeandidier is one of a group of people who are particularly interested in the intraperitoneal delivery of insulin for the physiological regulation of blood glucose in diabetic patients. This is why her support and experience are highly valued in the development of Defymed’s medical devices.

  • Professor of endocrinology, diabetes, metabolic diseases at the University of Strasbourg
  • More than twenty years of experience in the intraperitoneal delivery of insulin (peritoneal insulin infusion, implantable pumps, pumps –sensors, artificial pancreas, islet transplants)
  • Having been a member of the CEED since 2005, Nathalie was also president of the EVADIAC association (assessment of the active implant treatment of diabetes patients using active implants) between 2009 and 2012 and is currently the president of the scientific committee

Katja Schenke-Layland


Katja Schenke-Layland is an expert in stem cell and extracellular matrix biology as well as diagnostic tool development. One of her main research interests revolves around the role of the extracellular matrix in the establishment of patient-derived three-dimensional in vitro models for functional testing of compounds or medical devices such as the Defymed medical device.

  • Professor of Medical Technologies and Regenerative Medicine in the Department of Women’s Health at the Eberhard Karls University Tübingen, Germany
  • Director of the Natural and Medical Sciences Institute (NMI) Reutlingen at the University of Tübingen, Germany
  • Adjunct Associate Professor in the Department of Cardiology at the University of California in Los Angeles, USA
  • Executive editor for Advanced Drug Delivery Reviews and Co-Editor-in-Chief of Tissue Engineering
  • Member of the German Central Ethics Committee for Stem Cell Research

Eckhard Wolf


Eckhard Wolf studied Veterinary Medicine at the LMU Munich, Germany (1982-87).

  • Since 1995 he is Head of the Institute for Molecular Animal Breeding and Biotechnology, since 2003 Director of the Laboratory for Functional Genome Analysis (LAFUGA), and since 2014 Director of the Center for Innovative Medical Models (CIMM), LMU Munich.
  • His lab is specialized in the generation and characterization of genetically engineered pigs as models for human diseases (diabetes mellitus, rare monogenic diseases) and as organ donors for xenotransplantation.
  • Eckhard Wolf is Speaker of the Transregional Collaborative Research Center “Biology of xenogeneic cell, tissue and organ transplantation – from bench to bedside” funded by the German Research Council.
  • He is Member of the German National Academy of Sciences – Leopoldina (since 2000) and Corresponding Member of the Austrian Academy of Sciences (since 2014).

Michel Vix


Michel Vix is a specialist in gastrointestinal surgery for setting up and validating the surgical procedures used when implanting Defymed’s medical devices.

  • Digestive, endocrine and bariatric surgeon at the University Hospitals of Strasbourg
  • Joint scientific director of the IRCAD/EITS
  • As an opinion leader in bariatric and metabolic surgery, Michel is part of the scientific board of several companies
  • Took part in the project on “experimental, interfacial, analyses, retrieval and clinical follow-up studies of implants and medical devices” with Professor Stig Karlsson

Thierry Delair


Thierry Delair contributes his expertise to designing, drawing up and using innovative materials for tissue engineering.

  • Professor at the Claude Bernard University in Lyon and deputy director of the polymer material engineering laboratory where he carries out his research activity on the creation of biomaterials using polysaccharide assemblies
  • Managing research and development projects at BioMerieux for more than 20 years

Arnaud Scherberich


Arnaud Scherberich has expertise in the biology and therapeutic potential of mesenchymal stromal cells for regenerative surgery applications. His research involves the development of perfusion bioreactor-based models and the generation of pre-vascularized tissue grafts and devitalized engineered tissue matrices for therapeutic purposes, primarily in the context of bone regeneration.

  • He has completed his PhD in Pharmacology in December 1999 at the University of Strasbourg (France)
  • Since 2007, he is leading a biomedical engineering research team at the University of Basel, Switzerland.
  • Among many commitments, Arnaud is an elected member of the Executive Committee of the Swiss Society for Biomaterials and Regenerative Medicine (SSB+RM).

Jérôme Gloriod


Jérôme GLORIOD contributes his expertise in the design, design transfer and manufacture of Defymed’s medical devices.
• Jérôme has graduated as a biomedical engineer from the ISIFC of Besançon and has a DUT in mechanics
• Jérôme is now R&D manager at STATICE INNOVATION
• He has several years of experience as a project manager in the development of innovative medical devices using biomaterials, as silicone elastomer, plastics, metals, nitinol…

Arnaud Coudreuse


Arnaud Coudreuse gives guidance to Defymed in choosing the right materials and methods for enhancing the performance of its medical devices.

  • Arnaud has been working in CTTM for more than 25 years as a material expert. His area of expertise is polymer materials and surface treatments.
  • Arnaud was part of the original BARP+ project at CTTM which led to the realization of the first prototype of MailPan®
  • Arnaud has graduated at the Le Mans – Université du Maine and has a DEA in condensed matter physics